Image for a figure for an upcoming manuscript by Dr. Joaquin Espinosa at the University of Colorado illustrating that individuals with Down's Syndrome (trisomy 21) over-produce immune cytokines in response to COVID-19 infection. This means that when the covid-19 virus enters the respiratory epithelium, these cells over-produce interferons (IFNs) and trigger an immune system reaction to the infection that goes beyond the "cytokine storm" (which is typically responsible for killing individuals with COVID-19) and enters into the realm of a "cytokine hurricane". These individuals are therefore much more likely to require hospitalization and have a greater chance of dying from this virus than those people with two copies of chromosome 21 (euploidy 21). Image published in Espinosa JM, Down Syndrome and COVID-19: A Perfect Storm?, Cell Rep Med, 2020 May 19;1(2):100019, free to read at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252041/